Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein α Subunit Mutants
نویسندگان
چکیده
منابع مشابه
Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants.
GoLoco motif proteins bind to the inhibitory G(i) subclass of G-protein α subunits and slow the release of bound GDP; this interaction is considered critical to asymmetric cell division and neuro-epithelium and epithelial progenitor differentiation. To provide protein tools for interrogating the precise cellular role(s) of GoLoco motif/Gα(i) complexes, we have employed structure-based protein d...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.190496